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Joint Econometrics and Statistics Workshop

Exploring cross-trait genetic architectures: statistical models, computational challenges, and the BIGA platform

Bingxin Zhao (University of Pennsylvania), joint with Fei Xue and Yujue Li

Friday 16 June 2023 14:30 - 15:30

Many of our seminars and public events this year will continue as in person or as hybrid (online and in person) events. Please check our website listings and Twitter feed @STICERD_LSE for updates.

Unless otherwise specified, in-person seminars are open to the public.

Those unable to join the seminars in-person are welcome to participate via zoom if the event is hybrid.

About this event

Numerous statistical models have been proposed to analyze cross-trait genetic architectures utilizing summary statistics from genome-wide association studies (GWAS). However, systematically analyzing high-dimensional GWAS summary statistics presents logistical and computational challenges. In this talk, we introduce the BIGA platform (, a website that offers unified data analysis pipelines and centralized data resources. We have developed a framework that implements statistical genetics tools on a cloud computing platform, integrated with extensive curated GWAS datasets. Furthermore, we discuss our recent theoretical analyses of the LD score regression (LDSC), a widely-used method for inferring heritability and genetic correlation using GWAS summary statistics. We provide theoretical guarantees for LDSC-based estimators by explicitly modeling the block-wise dependence pattern of high-dimensional GWAS data. These analyses are joint work with Fei Xue and Yujue Li.

Econometrics and Statistics seminars are held on Fridays in term time at 12:00-13:00, ONLINE, unless specified otherwise.

Seminar organisers: Dr Tatiana Komarova and Dr Yunxiao Chen.

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